Rejuran Healer Trueskin Essence is the topical polynucleotide (c-PDRN) essence of PharmaResearch’s Rejuran line: two 2 mL prefilled syringes per box, applied to the skin with a microneedling device, derma roller or tok stick rather than injected. It shares the salmon-DNA c-PDRN chemistry of injectable Rejuran and carries no lidocaine. It is used in device-based protocols for skin texture, radiance and barrier support, for professional use.
What is Rejuran Healer Trueskin Essence?
Rejuran Healer Trueskin Essence is the topical polynucleotide essence of PharmaResearch’s Rejuran line. Where the injectable Rejuran products are placed into the dermis, this essence is applied to the surface of the skin and driven in with a device — a microneedling pen, derma roller or tok stick. Each box holds two 2 mL prefilled syringes of the essence.
Its active is polynucleotide (c-PDRN), the salmon-DNA-derived chain that the Rejuran family is built around. It carries no lidocaine and is not an anaesthetised injectable; it is a professional essence used alongside needling to support skin texture, radiance and the skin barrier.
How does the essence differ from injectable Rejuran?
The difference is the route. Rejuran Healer is injected into the dermis for repair; the Trueskin Essence is applied on top of the skin and delivered with microneedling, which suits clinics that run device-based polynucleotide protocols or that want a topping essence during a needling session. Both share the same c-PDRN chemistry; only the delivery and packaging differ.
| Trueskin Essence | Topical c-PDRN · 2 × 2 mL · applied with microneedling |
|---|---|
| Rejuran Healer | Injectable polynucleotide · 2 × 2 mL · dermal repair |
| Ami Eyes | Polynucleotide 1% · eye area |
What do clinics use it for?
It is commonly selected for skin-texture and radiance work delivered by microneedling: the essence is applied to the skin and the device carries it into the upper layers during the session. Technique, needle depth and session spacing follow the practitioner’s protocol, and suitability is assessed by the treating clinician.
Commonly selected for
- Microneedling protocols that use a polynucleotide essence
- Skin texture, radiance and barrier support
- Clinics already running the Rejuran line
- Sessions where a topical, non-injected option is preferred
How is it supplied?
Two 2 mL prefilled syringes per box. Store and handle per the manufacturer’s instructions for use.
Reviewed against publicly available manufacturer information. Indications, dosing and technique are product-specific per the manufacturer’s labeling and are decided by the treating clinician.
Specifications
| Brand | Rejuran® Healer Trueskin Essence (PharmaResearch) |
|---|---|
| Brand owner | PharmaResearch Co., Ltd. (South Korea) |
| Origin | South Korea |
| Active | Polynucleotide (c-PDRN) |
| Composition | Salmon-DNA-derived polynucleotide (c-PDRN); a topical essence, not an injectable; no lidocaine |
| Format | 2 mL prefilled syringe |
| Presentation | 2 prefilled syringes per box (4 mL total) |
| Areas | Face — texture, radiance, barrier support |
| Delivery | Applied topically into the skin with a microneedling device, derma roller or tok stick; not injected |
| Administration | For professional use |
| Storage & handling | Store and handle per the manufacturer’s instructions for use |
Frequently asked questions
Is the Trueskin Essence injected?
No. It is a topical essence, applied to the surface of the skin and driven in with a microneedling device, derma roller or tok stick. The injectable Rejuran products are separate.
What is the active ingredient?
Polynucleotide (c-PDRN), the salmon-DNA-derived chain the Rejuran line is built around. It contains no lidocaine.
How many syringes are in a box?
Two 2 mL prefilled syringes, four millilitres of essence in total.
How is it different from injectable Rejuran Healer?
Same c-PDRN chemistry, different route: the essence is applied on top of the skin and delivered by microneedling, while Rejuran Healer is injected into the dermis.
How should it be stored?
Store and handle per the manufacturer’s instructions for use.