Puri Coll Rh is WEDERM’s recombinant human collagen booster: 7.5 mg Type I plus 7.5 mg Type III collagen produced in yeast, with 50 mg hyaluronic acid, 30 mg succinic acid, 5 mg PDRN and four peptides in one 2.5 mL prefilled syringe. Positioned as a collagen biostimulator for lifting, wrinkles and dermal density on the face, eye area, neck and hands, it is placed in the deep dermis over two sessions one month apart. Professional use only.
What is Puri Coll Rh?
Puri Coll Rh is WEDERM’s recombinant human collagen booster. Each 2.5 mL prefilled syringe delivers 7.5 mg of recombinant human collagen Type I and 7.5 mg of Type III — produced in Pichia pastoris yeast rather than extracted from animal tissue — together with 50 mg hyaluronic acid, 30 mg succinic acid, 5 mg PDRN and four functional peptides. WEDERM positions it as a collagen biostimulator for lifting, wrinkle improvement and dermal density, with Type I supporting structure and Type III supporting regeneration.
How is a recombinant collagen booster different from PN or HA boosters?
Polynucleotide products such as Rejuran Healer signal the skin to repair; HA boosters hydrate. Puri Coll Rh supplies collagen directly — human-sequence, animal-free — alongside HA, PDRN and succinic acid, and is placed deeper (deep dermis, 2.5–3.5 mm) than a typical mesotherapy booster. Its closest stable-mate is Purihilo PN, which remodels with HA + PN but contains no collagen.
| Puri Coll Rh | Rh collagen I + III 15 mg + HA 50 mg + succinic acid + PDRN 5 mg · 1 × 2.5 mL · deep dermis |
|---|---|
| Purihilo PN | H+L HA 80 mg + PN 25 mg · 1 × 2.5 mL · BAP points |
| Puri PDRN | HA 25 mg + PDRN 5 mg + niacinamide · 5 × 2.5 mL · mesotherapy |
| Rejuran Healer | Polynucleotide only · 2 × 2 mL · dermal repair |
What do clinics use Puri Coll Rh for?
WEDERM lists the nasolabial folds, forehead and glabellar lines, crow’s feet and marionette lines, the eye area (dark circles, eye wrinkles, eye bags) and body sites including the neck, hands, elbows and knees. Delivery options are micro-papular or nappage injection with a 29–30G needle, retrograde linear threading with a 25–27G cannula, or BAP / K15+ point techniques at about 0.25 mL per bolus. The manufacturer’s course is two sessions one month apart, repeated after three to four months, with meso gun, microneedling, RF needling or fractional laser as adjuncts. Suitability and technique are decided by the treating clinician.
Commonly selected for
- Fine lines and loss of dermal density
- Under-eye crepiness and dark circles
- Neck, hand and body skin quality
- Patients preferring an animal-free collagen source
How is Puri Coll Rh supplied?
One 2.5 mL prefilled syringe per box; needles and cannulas are not listed as included. Store and handle per the manufacturer’s instructions for use.
Reviewed against publicly available manufacturer information. Indications, dosing and technique are product-specific per the manufacturer’s labeling and are decided by the treating clinician.
Specifications
| Brand | Aeterderm® Puri Coll Rh (WEDERM) |
|---|---|
| Manufacturer | WEDERM Co., Ltd. (Seoul, South Korea) |
| Origin | South Korea |
| Active | Rh collagen I + III 15 mg · HA · PDRN |
| Collagen source | Recombinant human collagen expressed in Pichia pastoris yeast (animal-free) |
| Format | 2.5 mL prefilled syringe |
| Presentation | 1 prefilled syringe per box |
| Areas | Face · eye area · neck · hands |
| Delivery | Micro-papular / nappage 29–30G, retrograde linear with 25–27G cannula, BAP or K15+ points at about 0.25 mL per bolus; deep dermis 2.5–3.5 mm (manufacturer) |
| Protocol | 2 sessions one month apart; repeat course after 3–4 months (manufacturer) |
| Administration | Injectable — by a qualified medical professional only |
| Storage & handling | Store and handle per the manufacturer’s instructions for use |
| Composition | Recombinant human collagen Type I 7.5 mg + Type III 7.5 mg · hyaluronic acid 50 mg · succinic acid 30 mg · PDRN 5 mg · peptides q.s. (galloyl tripeptide-35, nicotinoyl tripeptide-1, nicotinoyl octapeptide-1, acetyl hexapeptide-8) — per 2.5 mL |
Frequently asked questions
What is Puri Coll Rh used for?
For fine lines, loss of dermal density and skin laxity on the face, eye area, neck and hands, as a collagen booster combining recombinant human collagen with HA, PDRN and succinic acid.
What kind of collagen is it?
Recombinant human collagen Type I and Type III — human-sequence collagen produced in Pichia pastoris yeast, so it is animal-free. Each syringe contains 7.5 mg of each type (15 mg total).
How is it different from a PN booster?
A polynucleotide booster signals the skin to repair itself; Puri Coll Rh supplies collagen directly and is injected deeper, with PDRN and HA as supporting ingredients.
What is the suggested protocol?
Two sessions one month apart, repeated after three to four months, using nappage (29–30G), a 25–27G cannula or BAP/K15+ points at about 0.25 mL per bolus in the deep dermis. The treating clinician decides the plan.
How is it supplied?
One 2.5 mL prefilled syringe per box, without listed needles. Store per the manufacturer’s instructions.