Aeterderm Puri PDRN is a Korean skin booster from WEDERM Co., Ltd. combining 25 mg hyaluronic acid, 5 mg PDRN and 5 mg niacinamide in each 2.5 mL prefilled syringe (five per box). It is positioned for elasticity, hydration and brightening across the full face, delivered by meso-gun or nappage over a course of four sessions at 2–3-week intervals per the manufacturer, and is intended for qualified medical professionals only.
What is Aeterderm Puri PDRN?
Puri PDRN is a three-in-one Korean skin booster from WEDERM’s own Aeterderm brand. Each 2.5 mL prefilled syringe contains 25 mg hyaluronic acid, 5 mg PDRN (polydeoxyribonucleotide) and 5 mg niacinamide — HA for hydration, PDRN for regeneration and niacinamide for brightening and barrier support. The manufacturer positions it as an “Elastic & Rejuvenating” booster for the whole face. Five syringes per box.
How does Puri PDRN compare with Rejuran and Hyaron?
It occupies the middle ground between a pure HA booster and a pure polynucleotide. Hyaron is hyaluronate only; Rejuran Healer is polynucleotide only. Puri PDRN gives both in one syringe plus niacinamide, at a lower PDRN dose than Rejuran, which is why clinics often select it for maintenance and hydration-led programmes where full-strength PN is not the priority.
| Puri PDRN | HA 25 mg + PDRN 5 mg + niacinamide 5 mg · 5 × 2.5 mL · hydration + regeneration |
|---|---|
| Hyaron | Non-cross-linked HA 25 mg per 2.5 mL · 10 syringes · hydration only |
| Rejuran Healer | Polynucleotide, no HA · 2 × 2 mL · dermal repair |
| Curenex Glow | PDRN + peptides + HA + glutathione · 5 × 5 mL vials · radiance |
What do clinics use Puri PDRN for?
The manufacturer describes application to the dermal layer across the forehead, periocular area, cheeks, nasolabial folds, perioral area and chin, by meso-gun multi-needle (31–33G) or nappage with a 30–34G needle, as a main course of four sessions at 2–3-week intervals with a further course after 3–6 months. It is also described as an adjunct to microneedling, RF needling and fractional laser. All protocol decisions rest with the treating clinician.
Commonly selected for
- Hydration-led rejuvenation with a regenerative component
- Dull or uneven tone where niacinamide is wanted
- Maintenance between stronger PN courses
- Combination with energy-based or microneedling treatments
How is Puri PDRN supplied?
Five 2.5 mL prefilled syringes per box (syringes, not vials). Needles are not listed as a box component. Store and handle per the manufacturer’s instructions for use.
Reviewed against publicly available manufacturer information. Indications, dosing and technique are product-specific per the manufacturer’s labeling and are decided by the treating clinician.
Specifications
| Brand | Aeterderm® (WEDERM) |
|---|---|
| Manufacturer | WEDERM Co., Ltd. (Seoul, South Korea) |
| Origin | South Korea |
| Active | HA 25 mg · PDRN 5 mg · niacinamide 5 mg |
| Concentration | HA 10 mg/mL · PDRN 2 mg/mL · Niacinamide 2 mg/mL |
| Format | 2.5 mL prefilled syringe |
| Presentation | 5 prefilled syringes per box |
| Areas | Full face |
| Delivery | Meso-gun multi-needle (31–33G) or nappage with 30–34G needle (manufacturer guidance) |
| Administration | Injectable — by a qualified medical professional only |
| Storage & handling | Store and handle per the manufacturer’s instructions for use |
| Composition | Hyaluronic acid 25 mg · PDRN 5 mg · Niacinamide 5 mg (per 2.5 mL syringe) |
Frequently asked questions
What is Puri PDRN used for?
For hydration-led facial rejuvenation with a regenerative and brightening component: the manufacturer describes full-face dermal application for elasticity, hydration and tone.
How much PDRN does it contain?
5 mg per 2.5 mL syringe (2 mg/mL), alongside 25 mg hyaluronic acid (10 mg/mL) and 5 mg niacinamide, per the manufacturer’s composition.
Is Puri PDRN the same as Rejuran?
No. Rejuran is a polynucleotide-only product from PharmaResearch. Puri PDRN combines a lower PDRN dose with hyaluronic acid and niacinamide in one syringe.
What is the manufacturer’s suggested course?
A main course of four sessions at 2–3-week intervals, with an additional course after 3–6 months, delivered by meso-gun multi-needle or nappage. The treating clinician decides the actual protocol.
Are vials or syringes supplied?
Prefilled syringes — five 2.5 mL syringes per box. Needles are not listed as a component. Store per the manufacturer’s instructions.