Profhilo is IBSA’s bio-remodelling injectable: 64 mg of hyaluronic acid in one 2 mL syringe — 32 mg high-molecular-weight plus 32 mg low-molecular-weight HA bound into hybrid cooperative complexes by NAHYCO® thermal technology with no chemical cross-linker. Injected at five Bio Aesthetic Points per side of the face, 2 mL per session and two sessions a month apart, it is positioned for skin laxity of the face, neck and body. CE-marked since 2015; professional use only.
What is Profhilo?
Profhilo is IBSA’s bio-remodelling injectable and one of the highest-concentration HA skin products on the market: 64 mg of hyaluronic acid in a single 2 mL syringe, split equally between high-molecular-weight (1100–1400 kDa) and low-molecular-weight (80–100 kDa) HA. IBSA’s patented NAHYCO® process binds the two fractions thermally into hybrid cooperative complexes without any chemical cross-linker, giving a product that spreads widely through tissue yet persists longer than a plain non-cross-linked HA. On the market since 2015 and CE-marked.
How is Profhilo different from a filler or a skin booster?
It is neither. A filler is placed to add volume; a classic booster hydrates the dermis with fine microdroplets. Profhilo is injected as a small number of 0.2 mL boluses at five Bio Aesthetic Points (BAP) per side of the face, from which its low-viscosity complex spreads to address skin laxity across the malar, submalar and jawline zones. A standard course is two 2 mL sessions one month apart, with maintenance as the clinician sees fit.
| Profhilo | Hybrid HA 64 mg/2 mL, no cross-linker · 5 BAP points per side · laxity / bio-remodelling |
|---|---|
| SKINVIVE by Juvéderm | Cross-linked HA 12 mg/mL microdroplets · cheek smoothness |
| Restylane Skinboosters Vital | Stabilised HA 20 mg/mL · hydration and elasticity |
| Hyaron | Non-cross-linked HA 10 mg/mL · hydration mesotherapy |
What do clinics use Profhilo for?
IBSA positions it for laxity and loss of skin quality of the face — particularly the malar-zygomatic and submalar areas — and for the neck and body. Typical delivery is the BAP technique with a 29G ½″ needle, 0.2 mL per point, 2 mL per session, two sessions one month apart. Suitability, technique and maintenance intervals are decided by the treating clinician.
Commonly selected for
- Early to moderate skin laxity of the lower face
- Neck and décolleté crepiness
- Patients wanting improved skin quality without added volume
- Practices building a “bio-remodelling” service line
How is Profhilo supplied?
One 2 mL prefilled syringe per box. Store and handle per the manufacturer’s instructions for use.
Reviewed against publicly available manufacturer information. Indications, dosing and technique are product-specific per the manufacturer’s labeling and are decided by the treating clinician.
Specifications
| Brand | Profhilo® (IBSA Derma) |
|---|---|
| Manufacturer | IBSA Farmaceutici Italia Srl (Lodi, Italy) |
| Origin | Italy |
| Active | Hybrid H-HA + L-HA 64 mg / 2 mL |
| Concentration | 32 mg/mL total HA |
| Technology | NAHYCO® Hybrid Technology — thermal hybrid cooperative complexes, no chemical cross-linking agents (BDDE-free) |
| Format | 2 mL prefilled syringe |
| Presentation | 1 prefilled syringe per box |
| Areas | Face · neck · body |
| Regulatory | CE-marked (2015) |
| Administration | Injectable — by a qualified medical professional only |
| Storage & handling | Store and handle per the manufacturer’s instructions for use |
| Composition | Hyaluronic acid sodium salt 64 mg per 2 mL: 32 mg high-MW (1100–1400 kDa) + 32 mg low-MW (80–100 kDa) |
Frequently asked questions
What is Profhilo used for?
For skin laxity and loss of skin quality — chiefly the malar, submalar and jawline areas of the face, and also the neck and body — as a bio-remodelling treatment rather than a volumising filler.
Is Profhilo a filler?
No. It contains no chemical cross-linker and is not designed to add volume. It spreads from a few injection points to improve skin quality and laxity.
How much hyaluronic acid does it contain?
64 mg per 2 mL syringe — 32 mg high-molecular-weight HA and 32 mg low-molecular-weight HA, one of the highest HA concentrations in a skin injectable.
What is the standard Profhilo protocol?
The BAP technique: five points per side of the face, 0.2 mL per point, 2 mL per session, two sessions one month apart, then maintenance as the clinician decides. A 29G ½″ needle is typically used.
Does Profhilo contain lidocaine?
No. The composition is hyaluronic acid sodium salt in buffered saline only.